Dysregulation of body weight maintenance and opioid dependence are often treated as independent disorders.Here, we assessed the effects of both acute and long-term administration of morphine with and without chemogenetic activation of agouti-related peptide (AGRP)-expressing neurons in the arcuate nucleus (ARCAGRP neurons) to Lip Tint elucidate whe
Post-translational modifications of PRC2: signals directing its activity
Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3).This CACAO LUXE RAW HONEY complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development.The activity o
Internalized stigma in patients with schizophrenia: A hospital-based cross-sectional study from Nepal
Introduction The aim of this study was to examine the internalized stigma of mental illness in patients with schizophrenia visiting psychiatry outpatient in a tertiary level hospital in Kathmandu, Nepal, and to explore the associated sociodemographic and clinical factors.Methods This was a cross-sectional study, where participants were selected by
Household Welfare of Rice-fish Farmers: An Income-Expenditure Ratio Approach
The increase in agricultural land conversion activities can cause a decrease in rice productivity, while food demand is increasing.One of the alternatives that can be sought is land intensification through the rice-fish farming system.This study aims to determine the household income of farmers, household expenditures of farmers, and the welfare of
Transcriptome sequencing analysis of echovirus 30 infection reveals its potential pathogenesis
Echovirus 30 (E30) causes various diseases, such as viral encephalitis; aseptic meningitis; hand, foot, and mouth diseases; and acute flaccid paralysis.Related neurological infections are most concerning.However, the molecular mechanisms of E30 pathogenesis are not fully understood.There is a growing research interest in E30 as a cause of neurologi